Oxygen-induced mitochondrial biogenesis in the rat hippocampus

Brain Injury/TBI, Hyperbaric Oxygen Therapy (HBOT)

The hypothesis that damage to mitochondrial DNA by reactive oxygen species increases the activity of nuclear and mitochondrial transcription factors for mitochondrial DNA replication was tested in the in vivo rat brain. Mitochondrial reactive oxygen species generation was stimulated using pre-convulsive doses of hyperbaric oxygen and hippocampal mitochondrial DNA content and neuronal and mitochondrial morphology…

Visual light effects on mitochondria: The potential implications in relation to glaucoma

Eyes, Near Infrared (NIR)/Red Light Therapy

Light of different wave-lengths have the potential to interact with four major mitochondrial protein complexes that are involved in the generation of ATP. Neurones of the central nervous system have an absolute dependence on mitochondrial generated ATP. Laboratory studies show that short-wave or blue light (400-480nm) that impinges on the retina affect flavin and cytochrome…