Transcranial low-frequency pulsating electromagnetic fields (T-PEMF) as post-concussion syndrome treatment

Brain Injury/TBI, Pulsed Electro-Magnetic Field (PEMF) Therapy

A small but significant number of mild traumatic brain injuries (mTBI) result in development of persistent prolonged symptoms, including cognitive deficits, headaches, and mental fatigue. Such symptoms are called post-concussion syndrome (PCS), usually diagnosed according to the International Classification of Disease (ICD)-10 or the Diagnostic and Statistical Manual of Mental Disorder (DSM)-IV. However, the concept…

The National Brain Injury Rescue and Rehabilitation Study – a multicenter observational study of hyperbaric oxygen for mild traumatic brain injury with post-concussive symptoms

Brain Injury/TBI, Hyperbaric Oxygen Therapy (HBOT)

The National Brain Injury Rescue and Rehabilitation Project was established as a preliminary study to test the safety and practicality of multi-center hyperbaric oxygen administration for the post-concussive symptoms of chronic mild traumatic brain injury as a precursor to a pivotal, independent, multi-center, controlled clinical trial. This report presents the results for 32 subjects who…

Oxygen-induced mitochondrial biogenesis in the rat hippocampus

Brain Injury/TBI, Hyperbaric Oxygen Therapy (HBOT)

The hypothesis that damage to mitochondrial DNA by reactive oxygen species increases the activity of nuclear and mitochondrial transcription factors for mitochondrial DNA replication was tested in the in vivo rat brain. Mitochondrial reactive oxygen species generation was stimulated using pre-convulsive doses of hyperbaric oxygen and hippocampal mitochondrial DNA content and neuronal and mitochondrial morphology…

Hyperbaric oxygen alleviates secondary brain injury after trauma through inhibition of TLR4/NF-κB signaling pathway

Brain Injury/TBI, Hyperbaric Oxygen Therapy (HBOT)

The aim of this study was to investigate the efficacy of hyperbaric oxygen in secondary brain injury after trauma and its mechanism in a rat model. A rat model of TBI was constructed using the modified Feeney’s free-fall method, and 60 SD rats were randomly divided into three groups – the sham group, the untreated…

Use of a PEMF to Treat Complex TBI with Brain Gauge and Rivermead Outcome Measures

Brain Injury/TBI, Pulsed Electro-Magnetic Field (PEMF) Therapy

The US Centers for Disease Control (CDC) claims that about 2.5 million cases of death, hospital admissions and emergency visits occurred in 2010 for traumatic brain injury (TBI), but this is expected to be a significant underestimate. It is also estimated that about 5.3 million Americans are living with post TBI disabilities. Certain populations are…

SPECT Perfusion Imaging Demonstrates Improvement of Traumatic Brain Injury With Transcranial Near-infrared Laser Phototherapy

Brain Injury/TBI, Near Infrared (NIR)/Red Light Therapy

Traumatic brain injury (TBI) is a growing health concern affecting civilians and military personnel. Near-infrared (NIR) light has shown benefits in animal models and human trials for stroke and in animal models for TBI. Diodes emitting low-level NIR often have lacked therapeutic efficacy, perhaps failing to deliver sufficient radiant energy to the necessary depth. In…

Hyperbaric oxygen treatment for inflammatory bowel disease: a systematic review and analysis

Brain Injury/TBI, Hyperbaric Oxygen Therapy (HBOT), Inflammation and Pain

Traditionally, hyperbaric oxygen treatment (HBOT) has been used to treat a limited repertoire of disease, including decompression sickness and healing of problem wounds. However, some investigators have used HBOT to treat inflammatory bowel disease (IBD), including Crohn’s disease and ulcerative colitis. Comprehensive searches were conducted in 8 scientific databases through 2011 to identify publications using…

Transcranial, Red/Near-Infrared Light-Emitting Diode Therapy to improve cognition in chronic traumatic brain injury

Brain Injury/TBI, Near Infrared (NIR)/Red Light Therapy

Study reviews the general topic of traumatic brain injury (TBI) and research utilizing transcranial photobiomodulation (tPBM) to improve cognition in chronic TBI using red/near-infrared (NIR) light-emitting diodes (LEDs) to deliver light to the head. Transcranial Photobiomodulation improves mitochondrial function increasing oxygen consumption, production of adenosine triphosphate (ATP), and improving cellular energy stores. Nitric oxide is…

Hyperbaric Oxygen Therapy Can Improve Post Concussion Syndrome Years after Mild Traumatic Brain Injury – Randomized Prospective Trial

Brain Injury/TBI, Hyperbaric Oxygen Therapy (HBOT)

Traumatic brain injury (TBI) is the leading cause of death and disability in the US. Approximately 70-90% of the TBI cases are classified as mild, and up to 25% of them will not recover and suffer chronic neurocognitive impairments. The main pathology in these cases involves diffuse brain injuries, which are hard to detect by…

Hyperbaric oxygen therapy promotes neurogenesis: where do we stand?

Brain Injury/TBI, Hyperbaric Oxygen Therapy (HBOT)

Neurogenesis in adults, initiated by injury to the central nervous system (CNS) presents an autologous repair mechanism. It has been suggested that hyperbaric oxygen therapy (HBOT) enhances neurogenesis which accordingly may improve functional outcome after CNS injury. In this present article we aim to review experimental as well as clinical studies on the subject of…