Studies have shown that excess formaldehyde accumulation in the brain accelerates cognitive decline in people with Alzheimer’s disease (AD). Recently, reports from our research team revealed that red light treatment (RLT) improved memory in AD mice by activating formaldehyde dehydrogenase (FDH) and thus reducing formaldehyde levels. Here, we developed a medical RLT device to investigate the safety and efficacy of this device in older adults with mild to moderate AD.
Participants in the control group will continue their routine treatments and personalized daily care during the 24-week study period, including usual medicine, recreational therapy, and management of behavioral disorders following current guidelines. Except for the RLT intervention for the RLT group, all the other treatment strategies for the two groups will be the same.
Huang Nayan, Yao Dandan, Jiang Wenjing, Wei Cuibai, Li Mo, Li Wenjie, Mu Haiyan, Gao Maolong, Ma Zongjuan, Lyu Jihui, Tong Zhiqian, Safety and Efficacy of 630-nm Red Light on Cognitive Function in Older Adults With Mild to Moderate Alzheimer’s Disease: Protocol for a Randomized Controlled Study, Frontiers in Aging Neuroscience, Vol 12, 2020, https://www.frontiersin.org/article/10.3389/fnagi.2020.00143, DOI=10.3389/fnagi.2020.00143, ISSN=1663-4365