Levels of antioxidants in individuals with diabetes increase initially as a response to increases in reactive oxygen species (ROS) and later decrease due to reactions between free radicals and antioxidants. As the disease progresses, antioxidant mechanisms can be damaged in parallel to tissue damage, reducing antioxidant levels. Generalization should be avoided, however, due to increases in vitamin E levels due to hyperlipidemia and increases in ferritin levels due to of inflammation. The effects of antioxidants in organs are dependent on tissue physiology. Enzymatic antioxidants are more effective within cells, whereas non-enzymatic antioxidants have a greater effect in the extracellular environment.
In conclusion, this study investigated the antioxidant effects of PEMF in a rat model of diabetes. PEMF altered the levels of MDA, NO, MPO, SOD, and GSH, suggesting that it regulates diabetes-associated damage. PEMF exerts these effects by reducing oxidative stress and increasing antioxidant levels. These findings suggest that PEMF may become a widespread non-invasive treatment option for diabetes and its complications.
Gözen H, Demirel C, Akan M, Tarakçıoğlu M. Effects of pulsed electromagnetic fields on lipid peroxidation and antioxidant levels in blood and liver of diabetic rats. Eur J Ther 2017; 23: 152-8.